Preclinical CRO services for pharma and biotech pipelines
Base Científica is a boutique preclinical CRO that designs and runs custom in vitro assays, 2D and 3D cell models, ADMET studies and validated bioanalysis — in our own laboratories, under strict NDA, to ANVISA, FDA, EMA and ICH standards.
Prefere português? Pesquisa Pré-Clínica
What our preclinical CRO services cover
Every programme is designed around your molecule and your decision point. We build bespoke cellular models, ADMET packages and bioanalytical methods for small molecules, biologics, mRNA and advanced therapies.
Custom in vitro assays
Assay design and development built around your molecule and your endpoint — not a fixed catalogue.
- Cytotoxicity, viability, proliferation and apoptosis
- Reporter, kinase and receptor-binding assays
- Signalling pathway and target engagement readouts
- Immunomodulation and inflammation panels
2D and 3D cell models
Physiologically relevant models that de-risk decisions before you commit to in vivo work.
- Spheroids, organoid-like and co-culture systems
- Primary cells and disease-relevant cell lines
- STR-authenticated cell banks (ANSI/ATCC ASN-0002)
- Mycoplasma-tested, fully traceable material
ADMET and mechanism of action
Early absorption, distribution, metabolism, excretion and toxicity data to support candidate selection.
- Metabolic stability and permeability
- Plasma protein binding and CYP interaction
- Genotoxicity and organ-specific toxicity screens
- Dose-response and MoA characterisation
Regulated bioanalysis
Analytical and molecular bioanalysis with method validation ready for a regulatory dossier.
- LC-MS/MS, qPCR, dPCR and ELISA platforms
- Method development, qualification and ICH Q2(R2) validation
- Stability, sample logistics and chain of custody
- ANVISA, FDA, EMA and ICH aligned documentation
From scoping call to regulator-ready report
Scoping call
A PhD scientist — not a salesperson — maps your question, endpoints and constraints.
Technical proposal
Study design, controls, acceptance criteria, timeline and price in a single document.
Execution
Work runs in our own laboratories under strict NDA, with scheduled progress checkpoints.
Reporting
Raw data, statistics and an interpreted report you can hand to partners or regulators.
Preclinical CRO services, answered
What is a preclinical CRO?
A preclinical contract research organization runs the laboratory studies that take a candidate from discovery to first-in-human readiness — in vitro pharmacology, ADMET, mechanism of action and bioanalysis. Base Científica is a boutique preclinical CRO focused on custom in vitro and molecular work rather than off-the-shelf packages.
Which preclinical CRO services does Base Científica offer?
Custom in vitro assay design, 2D and 3D cell models, ADMET and mechanism-of-action studies, STR cell line authentication, and bioanalytical method development and validation under ICH Q2(R2).
Do you work with international sponsors?
Yes. We serve pharma, biotech, CROs and reagent manufacturers worldwide, working in English, with international shipping of samples and documentation aligned to ANVISA, FDA, EMA and ICH expectations.
How long does a preclinical study take?
Most custom in vitro and bioanalytical programmes run in 6 to 12 weeks from signed scope, depending on assay development needs. Cell line authentication is delivered in about 10 days.
Can you take on white-label work for another CRO?
Yes. We routinely act as the invisible laboratory arm for other CROs under strict NDA and never compete for your sponsor relationship.
Tell us the question your study needs to answer.
Send a briefing and a PhD scientist replies within 24 business hours with a study design, timeline and price.