National Launch of STR-Based Cell Line Authentication Service

Introduction

In the world of biological research and pharmaceutical development, the reliability of experiments depends on the authenticity of human cell lines. However, issues such as misidentification and cross-contamination remain persistent challenges. To address this, Base Científica developed an innovative national genetic authentication service , leveraging Short Tandem Repeats (STR) technology —a standard of excellence in forensic science now applied to cell line monitoring. This innovative service not only ensures research integrity but also aligns with regulatory standards, offering a practical, accessible, and impactful solution for the scientific community.

The Solution: STR-Based Cell Line Authentication

Objective:

The service aims to verify the identity of human cell lines by comparing genetic profiles with internationally recognized databases, ensuring traceability and reproducibility in research.

Main Features:

• STR Technology: A proven forensic tool tailored for mobile authentication.

• Filter Paper Compatibility: Simplified sample collection and shipping at room temperature, eliminating the need for dry ice or specialized logistics.

• Global Database Integration: Genetic profiles are compared against the ATCC® STR Profile Database, a trusted international standard.

Main Benefits

1. Error Prevention: Accurate identification avoids the use of misidentified or contaminated strains, protecting experimental results.

2. Logistical Ease: Collecting samples on filter paper simplifies the process, making the service accessible throughout Brazil.

3. Regulatory Compliance: Fully aligned with Anvisa 's requirements for quality control in cell therapy R&D.

4. Educational Impact: Promotes a culture of good practices in research laboratories, fostering scientific responsibility.

Impact on Research and Development

• Improved Reproducibility: Regular monitoring detects genetic changes caused by prolonged passages, ensuring consistent results.

• Cost and Time Savings: Prevents rework and waste resulting from unreliable data, optimizing research investments.

• Strengthening National Research: By offering a robust and accessible solution, the service enhances the quality and credibility of Brazilian biomedical research, paving the way for impactful publications and preclinical trials.

Conclusion

The adoption of STR-based cell line authentication represents a crucial advancement for Brazilian science. By ensuring the reliability of experimental models, this service not only improves research quality but also fosters a culture of accountability and traceability. With its practical and accessible approach, it empowers researchers to meet regulatory demands while driving innovation in biomedical research.

Erika Machado de Salles, PhD.